Human Molecular Genetics

Human Molecular Genetics PDF Book Detail Author: Tom Strachan
Publisher: Garland Science
ISBN: 1136844074
Category : Science
Languages : en
Pages : 782

Book Description
Human Molecular Genetics is an established and class-proven textbook for upper-level undergraduates and graduate students which provides an authoritative and integrated approach to the molecular aspects of human genetics. While maintaining the hallmark features of previous editions, the Fourth Edition has been completely updated. It includes new Key Concepts at the beginning of each chapter and annotated further reading at the conclusion of each chapter, to help readers navigate the wealth of information in this subject. The text has been restructured so genomic technologies are integrated throughout, and next generation sequencing is included. Genetic testing, screening, approaches to therapy, personalized medicine, and disease models have been brought together in one section. Coverage of cell biology including stem cells and cell therapy, studying gene function and structure, comparative genomics, model organisms, noncoding RNAs and their functions, and epigenetics have all been expanded.

Human Molecular Genetics

Human Molecular Genetics PDF Book Detail Author: T. Strachan
Publisher: Garland Pub
ISBN: 9780815341499
Category : Medical
Languages : en
Pages : 781

Book Description
Rev. ed. of: Human molecular genetics 3 / Tom Strachan and Andrew Read. 3rd ed. c2004.

Human Molecular Genetics

Human Molecular Genetics PDF Book Detail Author: Peter Sudbery
Publisher: Pearson Education
ISBN: 9780130428110
Category : Science
Languages : en
Pages : 364

Book Description
This second edition of Human Molecular Genetics continues to provide a clear introduction to this complex and fast moving field. Now updated and revised throughout, the material covered has been carefully selected and structured to provide a concise overview for students studying the subject as part of a general biology, genetics or medical degree. A milestone in science has been reached through the publication of draft sequences of the human genome and this is reflected in changes to the book. A new chapter details the methodology used, what was revealed about genome structure and evolution and how the genome sequence will be exploited in diagnosing and treating common diseases. The chapter on complex diseases has also been completely rewritten to reflect new strategies for searching for the genes involved in such disorders. Finally, the human genome project has opened up new prospects in population genetics and evolution and these are discussed in a rewritten chapter. Features * Concise, up-to-date introduction to the subject * "New "chapters on sequencing and structure of the human genome* "New "chapter on complex disorders, including population surveys using SNPs * "Fully revised" chapter on human population genetics and evolution* Boxed case studies and techniques * Includes important genetic disorders and genetic counselling * References updated through a linked Web site. The text is aimed at courses in Human Genetics, Human Molecular Genetics and The Molecular Basis of Disease taught within Biology, Biochemistry, Biomolecular Sciences, Biomedical Sciences, Genetics and medical and other health-care degrees. Peter Sudbery is Senior Lecturer in Genetics at the Department of Molecular Biology and Biotechnology at the University of Sheffield. "The Cell and Molecular Biology series provides introductions to key, exciting areas of cell and molecular biology, stimulating student's imaginations and initiative to bridge the gap between memorising concepts and the active approach needed for research and literature review projects. This active learning series also introduces students to experimental design and information retrieval and analysis, including exploration of the World Wide Web."

Human Molecular Genetics

Human Molecular Genetics PDF Book Detail Author: Peter Sudbery
Publisher: Benjamin-Cummings Publishing Company
ISBN:
Category : Science
Languages : en
Pages : 445

Book Description
This is a concise overview of a complex and fast moving field. The text explains amongst many things the special problems encountered in human genome analysis. Boxed case studies are incorporated to help student comprehension of this topic.

Human Molecular Genetics 3

Human Molecular Genetics 3 PDF Book Detail Author: T. Strachan
Publisher: Garland Science
ISBN: 9780815341826
Category : Medical
Languages : en
Pages : 708

Book Description
This work provides guidance on the principles underlying modern human molecular genetics. This new edition has been updated to take account of the changes in our understanding of this field since the late 1990s.

Human Molecular Genetics

Human Molecular Genetics PDF Book Detail Author: Stone
Publisher:
ISBN: 9780723430629
Category :
Languages : en
Pages :

Book Description

An Introduction to Human Molecular Genetics

An Introduction to Human Molecular Genetics PDF Book Detail Author: Jack J. Pasternak
Publisher: John Wiley & Sons
ISBN: 047171917X
Category : Science
Languages : en
Pages : 656

Book Description
An Introduction to Human Molecular Genetics Second Edition Jack J. Pasternak The Second Edition of this internationally acclaimed text expandsits coverage of the molecular genetics of inherited human diseaseswith the latest research findings and discoveries. Using a unique,systems-based approach, the text offers readers a thoroughexplanation of the gene discovery process and how defective genesare linked to inherited disease states in major organ and tissuesystems. All the latest developments in functional genomics,proteomics, and microarray technology have been thoroughlyincorporated into the text. The first part of the text introduces readers to the fundamentalsof cytogenetics and Mendelian genetics. Next, techniques andstrategies for gene manipulation, mapping, and isolation areexamined. Readers will particularly appreciate the text'sexceptionally thorough and clear explanation of genetic mapping.The final part features unique coverage of the molecular geneticsof distinct biological systems, covering muscle, neurological, eye,cancer, and mitochondrial disorders. Throughout the text, helpfulfigures and diagrams illustrate and clarify complex material. Readers familiar with the first edition will recognize the text'ssame lucid and engaging style, and will find a wealth of new andexpanded material that brings them fully up to date with a currentunderstanding of the field, including: * New chapters on complex genetic disorders, genomic imprinting,and human population genetics * Expanded and fully revised section on clinical genetics, coveringdiagnostic testing, molecular screening, and varioustreatments This text is targeted at upper-level undergraduate students,graduate students, and medical students. It is also an excellentreference for researchers and physicians who need a clinicallyrelevant reference for the molecular genetics of inherited humandiseases.

Human Molecular Genetics

Human Molecular Genetics PDF Book Detail Author: Ann Johnson
Publisher:
ISBN: 9781641724487
Category : Science
Languages : en
Pages : 235

Book Description
The biological field which deals with the study of inheritance in human beings is called human genetics. Human molecular genetics is one of its sub-fields where the functions and structure of human genes are studied at the molecular level. It uses tools from numerous fields such as genetics and molecular biology. Human molecular genetics finds application in the study of developmental biology as well as in the treatment of genetic diseases. There are a number of techniques which are used within this field such as forward genetics, reverse genetics and DNA replication. This book attempts to understand the multiple branches that fall under the discipline of human molecular genetics and how such concepts have practical applications. The topics covered herein deal with the core subjects of this field. This textbook will provide comprehensive knowledge to the readers.

Handbook of Human Molecular Evolution 2 Volume Set

Handbook of Human Molecular Evolution  2 Volume Set PDF Book Detail Author: David N. Cooper
Publisher: John Wiley & Sons Incorporated
ISBN:
Category : Science
Languages : en
Pages : 1717

Book Description
"This splendid compendium ... will be the standard reference work for years to come: a handbook to browse, to consult, to look things up in, and to read with pleasure, wonder and post-Darwinian exhilaration." —Richard Dawkins "This is a marvellous book… It should be in every university library - preferably in several copies - and every reader of this journal should add it to their next grant application. It really is that good... I have already found this book to be invaluable… For many years to come, these two volumes will be the starting point for anyone wishing to find out about virtually any subject relating to human genetics… Any scientist working on humans or other animals will find many things in these pages that will stimulate, inform and inspire. The authors, editors and publishers are to be congratulated for their work… order a copy now!" —HUMAN GENETICS "The publishers and editors deserve to be congratulated for publishing this major book which coincides with the 200th anniversary of the birth of Charles Darwin. The book is well-timed, with biologists, theologians and sociologists engaged in intense debate on the Darwinian Theory on the origin of species, evolution and natural selection… There is little doubt that this marvellous publication should be in the library of universities and academic institutions dealing with basic and applied biology research and education… It will not be surprising if the individual academic or researcher decides to invest in this resource and enrich their personal collection of leading books in genetics and genomics." —GENOMIC MEDICINE A Unique Collection of High-Quality Articles – Derived from the Acclaimed Encyclopedia of Life Sciences The revolution in human molecular genetics which has taken place over the last three decades has yielded a wealth of information not only on the structure and function of our genes, but also on gene expression, mutation and polymorphic variation. Over the last five years, the focus has moved from genes to genomes. Even though the annotation of our ~30,000 genes is still in progress, genome-wide studies have already yielded abundant evidence for the signatures of past selection and adaptive evolution within human gene sequences. Further, the completion of the sequencing of the 3 billion base-pair human genome, coupled with the increasing availability of other vertebrate genome sequences, has ushered in a new era of comparative genomics. We are now able to identify many of the molecular events (from the chromosomal level down to the single base-pair) that have occurred during vertebrate, mammalian, primate and hominid evolution. Indeed, the detailed comparison of the human and chimpanzee genomes has begun to reveal some of the genetic changes that have been involved in the development of human lineage-specific traits. We are thus acquiring the ability to ask searching questions about our origins, about the demographic processes associated with the global radiation of humankind, as well as some of the unique adaptations that make us human. Evolutionary biology has become so broad that its impact may be felt across the spectrum of the biological sciences. The aim of the Handbook of Human Molecular Evolution is relatively straightforward: to bring together under the same cover the many and varied strands of our knowledge of human/primate/vertebrate molecular evolution. Hence, the 282 chapters that comprise this essential reference work have been thematically arranged into twelve sections, covering the whole scope of research into human molecular evolution: General Concepts in Evolutionary Genetics Mutation, Adaptation and Natural Selection Evolutionary and Population Genetics Human Evolution Human Genome Evolution Evolution of Human Gene Structure and Function Evolution of Gene Expression Mitochondrial Genome Evolution Chromosomal Evolution Comparative Genomics Evolution and Disease Susceptibility Analysis of Ancient DNA This conceptual outline informed the selection of the chapters themselves and the connections between them. Some of these chapters are intended to be introductory, aimed at undergraduates and non-specialists. They provide basic information and a list of recommended further reading to encourage the reader to explore a topic in more depth. This approach helps the student reader progress from textbook material to primary literature. Some chapters are overviews that address topics of broad interest and importance, while others focus on quite specialized topics. These chapters are written for postgraduate students and research workers; they contain more detailed information and key references allowing the reader to investigate a specific area in more depth. This format allows professionals to use the books as a quick reference source. The chapters are richly supplied with website information to allow access to relevant data sources over the internet. The self-contained, peer-reviewed articles in this unique handbook have been written by leading scientists in each field. Key topics include the evolution of enzyme function, the use of nucleic acid divergence as a "molecular clock", the origin of non-functional or junk DNA, the role of gene duplication in the emergence of novel gene function and the identification of molecular changes responsible for various human characteristics especially those pertaining to infection, cognition, disease and disease susceptibility. The Handbook of Human Molecular Evolution has adopted an integrated approach to the study of human evolution and seeks throughout to emphasize the interplay between molecular genetic concepts and principles on the one hand, and information acquisition and interpretation on the other. In this way, it is hoped that the ‘documents of evolutionary history’ written into the fabric of our genome, will become accessible to the widest possible audience.

Protocols in Human Molecular Genetics

Protocols in Human Molecular Genetics PDF Book Detail Author: Christopher G. Mathew
Publisher: Springer Science & Business Media
ISBN: 1592594964
Category : Medical
Languages : en
Pages : 461

Book Description
Protocols in Human Molecular Genetics highlights the tremendous advances in our ability to work on the human genome that have emerged in the past few years. The latest techniques are set forth in the clear, concise, easy-to-follow format that is the hallmark of Humana's Methods in Molecular Biology series. Nearly two-thirds of the book is devoted to describing practical procedures comprising the widest range of new methodologies in human molecular genetics, with the rest focusing on their specific experimental and clinical applications. An essential tool for everyone - whether novice or seasoned expert - involved in the rapidly growing area of human genome studies.

Epigenetics

Epigenetics PDF Book Detail Author:
Publisher:
ISBN:
Category : Gene expression
Languages : en
Pages : 155

Book Description

Human Molecular Genetics

Human Molecular Genetics PDF Book Detail Author:
Publisher: Academic Press
ISBN: 0080536417
Category : Science
Languages : en
Pages : 500

Book Description
Human Molecular Genetics is a practical guide to the applications of molecular biology and genetics techniques to human cells. A wide range of experimental procedures for investigating human genes and genomes are presented. * * Mutation Detection in Human Genes - chemical mismatch cleavage, DNA mini-sequencing, SSCP method, RT-PCR, electrophoretic mobility shift assay (EMSA), protein truncation test, chromosome deletion analysis. * Gene Mapping, Cloning, Sequencing - gene linkage determination, large-capacity cloning system, cDNA isolation, differential display method, primer-based DNA sequencing. * Transcription: Promoters, Transcription Factors, mRNA, - promotor mutation analysis, transcription factor identification, mRNA-protein interaction characterization. * RNA Editing, Ribozymes, Antisense RNA-mammalian RNA editing assays, ribozymes as genetic tools, antisense RNA technology. * Genome Recombination, Amplification - recombination assays for mammalian cells, gene amplification measurement. * Receptors, Signal Transduction - intra-cellular receptor characterization, analysis of signal transduction genes. * The Mouse as a Model System for Human Molecular Genetics - mouse genome methods (mouse crosses, somatic cell hybrids, YACs), mouse model for cardiovascular disease.

Human Molecular Genetics

Human Molecular Genetics PDF Book Detail Author: Tom Strachan
Publisher:
ISBN:
Category :
Languages : en
Pages :

Book Description

Problems and Solutions for Strachan and Read s Human Molecular Genetics

Problems and Solutions for Strachan and Read s Human Molecular Genetics PDF Book Detail Author: David Matthes
Publisher: Wiley-Liss
ISBN: 9780471384144
Category : Science
Languages : en
Pages : 160

Book Description
This problems and solutions book, covering the molecular aspects of human genetics, will serve as a companion to the second edition of Strachan and Read's Human Molecular Genetics. There will be 22 chapters divided into seven parts (Fundamentals of genes and chromosomes, Fundamentals of DNA technology, Features of the human genome, Mapping the human genome, Comparative genomics, Human genetic diseases, Dissecting and manipulating genes). Within each chapter, there will be 5 - 10 multi-part open-ended problems, 5-10 review questions, 10 multiple choice questions. Where appropriate bioinformatics questions will also be included. The book will be heavily illustrated consisting of approximately 100 black and white photos and 200 black and white line drawings that will be designed and formatted similarly to its companion textbook. While the problems book is intended as a companion to Human Molecular Genetics it can also be used independently from the textbook by both students and instructors. Where most problems books are priced for students we envision that the book will be purchased most frequently by instructors and thus have priced it accordingly. However it still remains within reach for students who can purchase the textbook and problems book for under $100.00.

Human Gene Evolution

Human Gene Evolution PDF Book Detail Author: David Neil Cooper
Publisher: Elsevier
ISBN: 9780121878702
Category : Science
Languages : en
Pages : 520

Book Description
Presents the principles of human gene evolution in a concise and easy to understand fashion. Uses examples of how evolutionary processes have molded present day genes, drawn from the evolution of humans and other primates, as well as from more primitive organisms. With increasing attention in this expanding area, this review forms a timely publication of our current knowledge of this important field. Structure and function in the human genome The evolution of gene structure Mutational mechanisms in evolution